Ibuprofen reduces altitude sickness, US study says
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The anti-incendiary drug ibuprofen can reduce acute altitude sickness suffered by a quarter of the millions of Americans who pass to the mountains to ski or hike, according to a clinical study published Tuesday.
Grant Lipman, the Stanford University researcher who led the study, described altitude sickness as being like "a certainly nasty hangover."
The symptoms contain headache, fatigue, dizziness, nausea, vomiting and pinched appetite.
In the worst cases, altitude sickness can cause cerebral edema, some often fatal brain swelling.
Ibuprofen, each active ingredient in over-the-contrariwise painkillers like Advil, reduced altitude nausea symptoms by 26 percent in a study of 58 men and 28 women, Lipman and his examination team reported.
The study was published in the online version of the Annals of Emergency Medicine.
The study participants traveled to ~y area of the White Mountains northeast of Bishop, California, whither they spent the night at 4,100 feet.
At 8 am, they were given one or the other 600 milligrams of ibuprofen or a placebo control heading up a mountain to a platform area at 11,700 feet. There, they were given a assistant dose at 2 pm.
They therefore hiked to 12,570 feet, at which place they received a third dose at 8 pm preceding spending the night on the high hill.
Of the 44 participants who admitted ibuprofen, 19, or 43 percent, suffered symptoms of height sickness, whereas 29 of the 42 participants who admitted placebos had symptoms, according to the study.
In other bickering, ibuprofen reduced the incidence of the sickness by 26 percent, the report reported.
Among study participants who suffered height sickness, symptoms were less severe in the persons who took ibuprofen, the researchers reported.
At vainglorious altitudes, decreased atmospheric pressure reduces oxygen molecules in the melody, making it harder for people to respire.
Some researchers believe altitude sickness occurs for the reason that a lack of oxygen to the brain causes it to expand with fluids. Ibuprofen appears to bring the swelling, according to the Stanford researchers.
Other altitude sickness drugs are available, such taken in the character of acetazolamide and dexamethasone, but they have power to have more undesirable side effects than ibuprofen, according to the researchers.
Ibuprofen's milder interest effects can include the possibility of gastrointestinal and kidney problems in commonalty who are dehydrated, the researchers related.
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